The party alleges that whilst voters in the region were subjected to the strict use of voter verification machines, voting in other parts of the country went on without verification when the machines broke down.
The party has drafted a petition to be submitted to the Electoral Commission to climax the protest.
Ashanti regional chairman of the NPP, Fredrick Fredua Antoh, told Joy News the protest march id not detract from the party's decision to challenge the election result in court.
He assured that the protest would be violence-free.
The Labour and Suame Roundabouts will serve as starting points for the two-pronged demonstration which will end at the Ashanti regional office of the Electoral Commission.
Luv FM’s Ohemeng Tawiah who is joining the marchers, reported that supporters of the party have started filing in for the peaceful protest.
The Police in Ashanti region say they are determined to make sure the march is conducted in an orderly manner.
According to the Public Relations Officer of the Ashanti Regional Police Command, ASP Mohammed Tankoh, measures have been put in place to ensure the march passes off without any hitches.